195. Pesticides

Rodenticides

Various formulations; not just superwarfarin. Superwarfarin stays in the system longer than warfarin – up to 16-60 days. First clotting factor to be affected is Factor VII (4-6 hours, though can take 20 hours before noting any INR change). Toxic dose for superwarfarin is 1g/kg (1 packet typically). If INR <4 and asymptomatic, no contact sports. If > 4, PO Vitamin K, long term hemotology followup. If no life threatening bleeding, given PO Vitamin K. If life threatening bleeding, do typical warfarin tx – PCCs, IV Vitamin K, DIC panel. (USC Rounds, 2017).

195. Pesticides

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